Current gene sequencing methods are highly wasteful. Traditional “flow cell” systems discard over 99% of expensive reagents after each use. Attempts to reduce waste, like immersion or surface coating methods, have issues like bubble formation, uneven reagent distribution, and evaporation—making them inefficient and costly, especially for small-scale testing.
Innovation
This invention introduces a new gene sequencing device that reuses reagents within each sequencing cycle, drastically reducing waste. Instead of flowing reagents over fixed samples, it places the sequencing chip inside a sealed, rotating chamber. As the device spins, reagents are distributed evenly by centrifugal force, and after the reaction, they are pulled back into a recovery tank for reuse.
What’s Unique
The key innovation lies in reagent recycling without valves or complex systems. By carefully designing the geometry and rotation speeds, the system uses natural forces (like surface tension and centrifugal force) to control the movement of fluids—no electronic valves needed. It also features capillary-sized recovery channels that prevent premature reagent loss.
Benefits
- Saves money: Significantly reduces the amount of reagent needed (one of the biggest sequencing costs).
- Efficient: Reagents can be reused 2–300 times before being replaced.
- Scalable: Works for both small and large sample sizes.
- Accurate: Uniform reagent distribution ensures more consistent results.
- Simpler and cheaper: The design minimizes moving parts and complexity.
Broader Impact
By making gene sequencing cheaper and more accessible, this technology could accelerate advances in medicine, agriculture, and biotech—supporting personalized healthcare, disease detection, and research even in resource-limited settings. It also contributes to sustainability by slashing chemical waste.